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New Houston bioindustrial accelerator to spark biotech-based sustainability

The BioWell, founded by biotech investor First Bight Ventures, was established to support sustainability-focused bioindustrial startups. Photo via Getty Images

Bioindustrial technologies have a high potential for impacting sustainability — but they tend to need a little bit more help navigating the startup valley of death. That's where the BioWell comes in.

Carlos Estrada, head of Venture Acceleration at BioWell, says the idea for the accelerator was came to First Bight Ventures, a Houston-based biomanufacturing investment firm, as it began building its portfolio of promising companies.

"While we were looking at various companies, we found ourselves finding different needs that these startups have," Estrada says on the Houston Innovators Podcast. "That's how the opportunity for the BioWell came about."

Specifically, bioindustrial companies, which are tapping into life science innovation to create more sustainable products or services, need early funding, lab space, and strategic corporate partners to help research and develop their startups.

"The very direct challenge that we are seeing is that these companies very often have to spend their funds to build out their own lab spaces," Estrada says, "so by the time they're trying to focus back on the product itself, they are starting to run out of funding."

Carlos Estrada, head of Venture Acceleration at BioWell, joins the Houston Innovators Podcast to share why Houston is already a great hub for bioindustrial innovation. Photo courtesy of BioWell

BioWell is currently selecting its inaugural cohort and is also actively searching for its physical location to build out the program and facilities. Last year, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program from the U.S. Economic Development Administration.

In addition to solving for specific challenges bioindustrial companies face, Estrada says the program will provide support for general startup and entrepreneurial guidance, like business plan development, navigating investors and grant funding, and more.

Just as First Bight Ventures was founded strategically in Houston to make the most of the local resources, the BioWell will operate out of the Bayou City — a market Estrada says has everything the industry needs.

"We have the right talent — our universities produce great researchers. We have the energy companies that are utilizing (a workforce) with transferable skills," he says on the show. "We also have the infrastructure, the square footage, and various real estate companies creating shells for lab space. We have the know how, the universities, and all at a lower cost, which plays a big role in the equation."

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This article originally ran on InnovationMap.

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A View From HETI

Four Houston scientists have been awarded funding through the Department of Energy's Genesis Mission. Photos courtesy

The U.S. Department of Energy has named the nearly 300 projects selected under the Trump Administration's Genesis Mission, which aims to address some of the largest science and technology challenges in the country. The group features four projects from Houston universities and companies.

The initiative aims to unite government, industry, academia and philanthropy to lead to breakthroughs in energy, scientific discovery and national security, according to a release.

The selected projects feature 87 led by DOE and National Nuclear Security Administration (NNSA) National Laboratories, 168 led by universities, 19 led by companies and 4 led by nonprofit organizations—totalling 342 participating institutions.

“America has no shortage of bold ideas or talented scientists, and the response to the Genesis Mission proves that,” U.S. Secretary of Energy Chris Wright said in a news release. “The 278 projects selected today represent the very best of our nation’s scientific enterprise. The remarkable number of high-quality proposals we received demonstrates that America’s innovation pipeline is strong, and it points to even greater opportunities for future investment and continued expansion of the Genesis Mission portfolio.”

Twelve Texas-based projects were selected among the 278. The Houston projects and their researchers include:


Caroline Ajo-Franklin

Ajo-Franklin recieved a Phase I grant for her project "Predictive AI to Map Point Mutation Effects on Protein Function: Measurement and Biosynthesis of Isoprenoids." Ajo-Franklin is a professor of biosciences at Rice University, a CPRIT Scholar in Cancer Research and member of the Rice Synthetic Biology Institute. The project aims to accelerate the engineering of microbes that can produce isoprenoids, which are natural compounds that could replace petroleum-derived fuels, solvents and materials.

“This project creates a continuous feedback loop in which AI guides experiments and each experiment generates more detailed data to better hone the AI model,” Ajo-Franklin said in a news release. “In addition, it demonstrates the extraordinary star power Rice has recruited in protein engineering and synthetic biology.”

Anastasios Kyrillidis

Kyrillidis recived a Phase I grant for his project "Cracking the VQA Optimization Bottleneck: AI Methods for Quantum Chemistry and Materials." Kyrillidis is the Noah Harding Associate Professor of Computer Science at Rice and a member of the Ken Kennedy Institute. The project aims to develop AI tools to resolve bottlenecks in quantum computing for chemistry and materials research.

“Our goal is to replace fragile, hand-tuned optimization methods with intelligent systems that can learn from quantum computations while still operating within frameworks that provide strong mathematical guarantees,” Kyrillidis added in the release.

Myoungkyu Lee

Lee received a nearly $750,000 Phase I grant for his project "Physics-Informed AI Surrogates for Turbulent Forced Convection in Energy System." Lee is an assistant professor of mechanical aerospace engineering at the University of Houston. Lee will collaborate with researchers from Lawrence Livermore National Laboratory and University of Pennsylvania on the project and develop artificial intelligence to accelerate the design of materials for advanced nuclear fission and fusion reactors.

“The goal is to develop a tool that runs much faster than today’s most detailed simulations while keeping errors small,” Lee said in a news release. “If successful, the approach could support better heat-transfer predictions for molten-salt reactor design and provide a starting point for studying heat removal in fusion blankets. This is one contribution among many toward reliable, carbon-free energy.”

Amit Padhi

Padhi recieved a grant for his project "Probabilistic Inference of Subsurface Fracture Connectivity for Stimulation Control with Physics-Informed AI." Padhi is a scientific advisor for Halliburton.

The DOE first called for applications for the Genesis Mission in March. At the time, the DOE shared that it would grant approximately $293 million to the selected teams via Phase I awards, ranging from $500,000 to $750,000 for nine-month project periods, and Phase II awards, for $6 million to $15 million over a three-year project period.

Since then, however, the initiative has grown with 15 federal agencies now granting research awards and funding opportunities under the Genesis umbrella. The White House announced this week that it had secured more than $5 billion in federal commitments to expand the initiative.

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