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New Houston bioindustrial accelerator to spark biotech-based sustainability

supporting startups

The BioWell, founded by biotech investor First Bight Ventures, was established to support sustainability-focused bioindustrial startups. Photo via Getty Images

Bioindustrial technologies have a high potential for impacting sustainability — but they tend to need a little bit more help navigating the startup valley of death. That's where the BioWell comes in.

Carlos Estrada, head of Venture Acceleration at BioWell, says the idea for the accelerator was came to First Bight Ventures, a Houston-based biomanufacturing investment firm, as it began building its portfolio of promising companies.

"While we were looking at various companies, we found ourselves finding different needs that these startups have," Estrada says on the Houston Innovators Podcast. "That's how the opportunity for the BioWell came about."

Specifically, bioindustrial companies, which are tapping into life science innovation to create more sustainable products or services, need early funding, lab space, and strategic corporate partners to help research and develop their startups.

"The very direct challenge that we are seeing is that these companies very often have to spend their funds to build out their own lab spaces," Estrada says, "so by the time they're trying to focus back on the product itself, they are starting to run out of funding."

Carlos Estrada, head of Venture Acceleration at BioWell, joins the Houston Innovators Podcast to share why Houston is already a great hub for bioindustrial innovation. Photo courtesy of BioWell

BioWell is currently selecting its inaugural cohort and is also actively searching for its physical location to build out the program and facilities. Last year, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program from the U.S. Economic Development Administration.

In addition to solving for specific challenges bioindustrial companies face, Estrada says the program will provide support for general startup and entrepreneurial guidance, like business plan development, navigating investors and grant funding, and more.

Just as First Bight Ventures was founded strategically in Houston to make the most of the local resources, the BioWell will operate out of the Bayou City — a market Estrada says has everything the industry needs.

"We have the right talent — our universities produce great researchers. We have the energy companies that are utilizing (a workforce) with transferable skills," he says on the show. "We also have the infrastructure, the square footage, and various real estate companies creating shells for lab space. We have the know how, the universities, and all at a lower cost, which plays a big role in the equation."

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This article originally ran on InnovationMap.

Calling all biotechnology startups focusing on sustainable feedstocks, commercially viable yields, and purpose fit microbes. Photo via Getty Images

Houston organization rolls out new accelerator to support companies tackling 'pressing global challenges'

CALLING FOR APPLICANTS

A Houston organization — freshly funded by a $700,000 U.S. Economic Development Administration’s “Build to Scale” grant — is seeking its first accelerator cohort of industrial biology startups.

Founded by Houston-based First Bight Ventures, the BioWell has launched a virtual accelerator program that will provide programming, networking, mentorship, and financial resources to its inaugural cohort of 10 bioindustrial startups. The selected companies will also have access to specialized pilot bioproduction infrastructure throughout the nine-month program.

“BioWell equips startups with more than just capital. We provide a foundation for breakthrough innovations by combining access to cutting-edge bioproduction facilities with expertise that nurtures scalability. This comprehensive support is crucial for transforming pioneering ideas into market-ready solutions that can address pressing global challenges,” Carlos Estrada, head of venture acceleration at BioWell, says in a news release.

Applications for the program are open until May 15, and the cohort will be announced in June. Specifically, BioWell is seeking seed or pre-seed startup applicants that have a technology readiness level of 3 to 5, focusing on areas including low-cost and sustainable feedstocks, commercially viable yields, and purpose fit microbes.

“During our selection process, we'll prioritize startups that demonstrate a commitment to not only hitting milestones but also to building sustainable revenue streams for long-term survival. This phase necessitates keen awareness of market dynamics, customer demands, and sound financial management,” adds First Bight Ventures and BioWell Founder Veronica Wu.

In December, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

Ex-Apple exec Wu founded First Bight Ventures in Houston in 2022 after relocating from Silicon Valley and seeing the region's potential for biotech.

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This article originally ran on InnovationMap.

First Bight Venture's BioWell has received a $741,925 grant to continue supporting bioindustrial startups. Photo via Getty Images

Houston nonprofit accelerator receives grant funding to advance bioindustrial startups

the biowell

A Houston-based nonprofit accelerator that works with early-stage synthetic biology startups has secured nearly $750,000 to support its mission.

First Bight Ventures' accelerator, BioWell, secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

The funding will support the BioWell's mission to establish a "vibrant bioeconomy" by helping startups scale and commercialize "through access to a unique combination of pilot bioproduction infrastructure," according to a news release from First Bight.

"Startups at BioWell will gain access to a robust ecosystem, expertise, mentorship, and financial resources essential for successfully commercializing their bio-industrial innovations," BioWell Executive Director Paul Palmer says in the release.

The BioWell is still working toward establishing a physical space and has worked out of the East End Maker Hub in the meantime. The organization has partnered with Urban Partnerships Community Development Corporation, or UP CDC, which led the application process on this federal grant.

"BioWell chose to partner with UP CDC for the EDA grant, to continue the successful model that UP CDC has created at the East End Maker Hub for advanced manufacturing. UP CDC looks forward to continuing our partnership with BioWell in the UP CDC's BioCity project that will position Houston at the forefront of bio-manufacturing," UP CDC's CEO Patrick Ezzell says in the release.

First Bight Ventures Founder Veronica Wu established the BioWell to target high-potential startups, which usually have to overcome lack of funding challenges early on.

"Often times, early-stage startups gain momentum and hit important milestones, but ultimately find themselves heading toward the 'Valley of Death,' where progress is made on their enterprise, but no sufficient revenue is generated for the company's stability and longevity," Wu says in the release. "This 'Build to Scale' program's support will help offset these inevitable challenges in our bio-industrial space."

She shares more about her mission for First Bight Ventures on the Houston Innovators Podcast. Listen to the interview from March below.

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This article originally ran on InnovationMap.

Algenesis bills its patented Soleic technology as the world’s first renewable, high-performance, fully biodegradable, and backyard-compostable polyurethane made from plants and algae. Photo via AlgenesisMaterials.com

Houston VC invests in early stage California biodegradable plastics startup

seed funding

Houston-based venture capital firm First Bight Ventures led a $5 million seed round for Encinitas, California-based startup Algenesis, a developer of biodegradable plastics.

Algenesis bills its patented Soleic technology as the world’s first renewable, high-performance, fully biodegradable, and backyard-compostable polyurethane made from plants and algae. Each year, 25 million tons of hard-to-recycle polyurethane are produced for the footwear, medical, and textile industries. Polyurethane, typically made from petroleum, usually ends up as landfill waste or environmental microplastics.

Algenesis says Soleic can biodegrade in compost within a matter of months and does not contain harmful PFAS chemicals found in other plastics.

Algenesis says the new funding will enable it to expand beyond soft-foam applications, such as midsoles and insoles for footwear, and into injection-molded products such as smartphone cases along with waterproof textiles.

Aside from First Bight Ventures, investors in the seed round are Singapore-based Circulate Capital, India-based MIH Capital, Chesapeake, Virginia-based Diamond Sports Group, and France-based Rhinoshield.

The investment comes on the heels of a $5 million grant Algenesis received from the U.S. Department of Energy to scale up production of biochemicals.

“To save our planet and ourselves, we must move away from petroleum-based plastics and toward bio-based alternatives. Algenesis is clearly at the forefront of making this possible,” says Veronica Wu, founder of First Bight Ventures.

First Bight, which launched in 2022, invests in early-stage startups working on synthetic biology.

“First Bight is investing to bring the best and the brightest — and most promising — synthetic biology startups from around the country to Houston,” Wu said last year.

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Here are 20+ CERAWeek 2025 events featuring Houston energy leaders

where to be

CERAWeek 2025 will host more than 1,400 speakers at its annual energy-focused conference taking place March 10-14, with many hailing from Houston.

Under this year's theme, "Moving Ahead: Energy strategies for a complex world,” panels will tackle topics ranging from policy and regulation, geopolitics, power, grid, and electrification, AI and digital, managing emissions, and more.

Most of the innovation-themed events are organized under the Agora track and will feature many Houston-area startups, universities, companies, and scientists. Here are all the events on the Agora track you can't miss if you want to learn more about Houston energy innovation.

Transition in Action: Energy giants shaping a sustainable future

ExxonMobil's Senior Director, Climate Strategy & Technology Vijay Swarup will examine how major energy companies are driving energy transition goals along with panelists from S&P Global, Aramco Ventures and Gentari Sdn Bhd.

This panel is from 12:30-1 p.m. on Monday, March 10. More info here.

Syzygy Plasmonics | Deploying the World’s Most Economic Biogas to SAF Technology

Hear from Syzygy Plasmonics CEO Trevor Best about how the cleantech company's catalyst and reactor work and how the tools can dramatically reduce the cost of producing SAF from biogas from landfills, wastewater, and dairy farms.

This panel is from 2-2:30 p.m. on Monday, March 10. More info here.

Cemvita | The Future of Bioengineered Feedstocks: A Foresight Perspective

Cemvita CEO Moji Karimi will lead this panel.

This panel is from 4:30-5:15 p.m. on Monday, March 10. More info here.

Innovating with Purpose: Strengthening industrial-academic partnerships

David Dankworth, ExxonMobil's Hydrogen Technology Portfolio Manager, and Brian Korgel, the University of Texas Energy Institute Director, will be joined by leaders from MIT and S&P Global to discuss the crucial relationship between universities and industry in fostering purpose-driven innovation.

This panel is from 8:30–9 a.m. on Tuesday, March 11. More info here.

Solidec | Low-cost, Low-carbon Chemicals from Air

Solidec co-founder and CEO Ryan DuChanois will discuss how the company's approach to producing hydrogen peroxide and other key chemicals can be low-cost and low-carbon, creating a scalable path for a more sustainable chemical industry.

This panel is from 9-9:30 a.m. on Tuesday, March 11. More information here.

Collaboration Spotlight: The Carbon Hub: A public-private partnership leading the way to a sustainable carbon economy

Panelists from Rice University, Huntsman Advanced Materials, CERAWeek, The Kavli Foundation, and SABIC will discuss Rice's Carbon Hub's transformative power and what the future looks like for those creating this new carbon economy. Matteo Pasquali, the founding Director of the Carbon Hub, will be featured on the panel.

This panel is from 9:30-10 a.m. on Tuesday, March 11. More information here.

Rice University | Next-generation Electrolyzers and Electrolysis

Haotian Wang, Associate Professor in the Department of Chemical and Biomolecular Engineering at Rice University and co-founder of Solidec, will discuss the development of next-generation electrolyzers that enable lower-cost and more energy-efficient carbon capture, chemical manufacturing and critical metal recovery.

This panel is from 9:30–10:15 a.m. on Tuesday, March 11. More information here.

ExxonMobil | Real-world Progress on Building a Low-carbon Business

Schuyler Evans, ExxonMobil's CCS commerical and business development manager low carbon solutions, will speak on how the energy giant is navigating a complex energy transition and share insights into the strategic thinking behind building a new business that helps reduce emissions.

This panel is from 10-10:30 a.m. on Tuesday, March 11. More information here.

Enovate.AI | AI-driven Advantage: Automate. Optimize. Decarbonize.

Enovate.AI Chief Experience Officer Rebecca Nye, joined by Last Mile Production, will show how its 3-clicks digital strategy empowers operators to make faster, smarter decisions—reducing emissions, enhancing productivity and unlocking new levels of profitability.

This panel is from 10:30–11 a.m. on Tuesday, March 11. More information here.

Financing the Future: Scaling clean energy through innovative investment strategies

Jim Gable, president of Chevron Technology Ventures and vice president of innovation, along with Greentown Lab's new CEO Georgina Campbell Flatter, will discuss the bankability of technologies in different geographies, investment opportunities in emerging markets, sources of funding and risk management strategies investors are using. Panelists also include leaders from Siemens Energy, Energy Impact Partners, and S&P Global Commodity Insights.

This panel is from 12:30–1:10 p.m. on Tuesday, March 11. More information here.

Sage Geosystems | Geothermal at the Speed of Need: How Sage Geosystems is meeting growing energy demand

Learn from Jason Peart, general manager of strategy and development, how Sage's approach to geothermal technology is tackling the fast-growing energy demands of critical sectors, including data centers, utilities, energy storage, and US Department of Defense projects.

This panel is from 1:30–2 p.m. on Tuesday, March 11. More information here.

Rice University | Valuing Nature-based Solutions for CO2 Removal

Carrie Masiello, director of the Rice Sustainability Institute, will introduce to the breadth of nature-based solutions possible, explore some of the most exciting opportunities and give guidance on how to think rigorously about matching individual NBS opportunities to specific portfolio needs.

This panel is from 1:30–2:15 p.m. on Tuesday, March 11. More information here.

Square Robot | Bridging the Divide: How Square Robot's tank inspections align corporate strategy with on-the-ground reality

Square Robot CEO David Lamont will discuss how companies can keep their tank assets online by adopting new technology and navigating the challenges of aligning corporate objectives with site-level realities.

This panel is from 3–3:30 p.m. on Tuesday, March 11. More information here.

The Green Gold Rush: A multi-trillion dollar opportunity?

Bobby Tutor, chairman of Houston Energy Transition Initiative and CEO of Artemis Energy Partners, will be joined by leaders from Accenture, S&P Global, and BeyondNetZero to discuss the immense economic potential of climate solutions and highlight the business opportunities created by the transition to a low-carbon economy.

This panel is from 4–4:30 p.m. on Tuesday, March 11. More information here.

ExxonMobil | Applying Technology to Maximize Value in the Permian Basin

James Ritchie, Exxon's vice president upstream technology portfolio, will share the latest technologies being developed and deployed to improve recovery and capital efficiency in the Permian Basin and demonstrate how these technologies and innovations maximize overall value while reducing greenhouse gas emissions and water usage.

This panel is from 2:30–3 p.m. on Wednesday, March 12. More information here.

Rice University | Plasma Foundry for Scalable Industrial Decarbonization

Aditya Mohite, a Rice professor and the faculty director of the Rice Engineering Initiative for Energy Transition and Sustainability (REINVENTS), will share how The Plasma Foundry, a 1:1 customized accelerator at Rice, is using cold plasma technology and its accelerator model to provide disruptive solutions at scale.

This panel is from 9:30–10:15 a.m. on Thursday, March 13. More information here.

Fervo Energy | Speed and Scale: The Geothermal Decade Is Now

Quinn Woodard Jr., Fervo Energy's senior director, power generation and surface facilities, will discuss how the company is pioneering transformative EGS technology to power data centers, homes and beyond.

This panel is from 10:30–11 a.m. on Thursday, March 13. More information here.

Corrolytics | Digitizing and Revolutionizing Corrosion Detection and Monitoring for Industrial Assets

Anwar Sadek, Corrolytics co-founder and CEO, will share how the company is revolutionizing corrosion detection and monitoring with patented technology to proactively enhance safety, reduce costs and extend asset lifespan.

This panel is from 10:30–11 a.m. on Thursday, March 13. More information here.

Zeta Energy | The Rise of Lithium-Sulfur Batteries: A solution to critical metal constraints

Rodrigo Salvatierra, Zeta's chief science officer, will introduce Zeta Energy’s lithium-sulfurized carbon technology, which effectively addresses the key limitations of lithium-sulfur batteries.

This panel is from 3–3:30 p.m. on Thursday, March 13. More information here.

Future Cities on the Move: Innovative pathways for sustainable urban mobility

Lisa Lin, Harris County's director of sustainability, will speak on this panel on successful public-private partnerships driving innovation in sustainable transport by leveraging technology and data analytics. She'll be joined by Aberdeen's council co-lead and leaders from S&P Global and GreenCap, based in Cape Town, South Africa.

This panel is from 3:30–4 p.m. on Thursday, March 13. More information here.

Collaboration Spotlight: Building a resilient Gulf Coast energy and chemical sector

Greater Houston Partnership and HETI's Jane Stricker will join Ramanan Krishnamoorti from the University of Houston and leaders from Argonne National Laboratory and SABIC to explore opportunities and pathways to strengthen the US Gulf Coast’s global leadership position in base chemical manufacturing and the national security and economic opportunities that innovation and process integration create.

This panel is from 4:30–5 p.m. on Thursday, March 13. More information here.

NRG Energy forms joint venture to build power plants for ERCOT and AI-driven demand

teaming up

Houston-based power provider NRG Energy Inc. has formed a joint venture with two other companies to meet escalating demand for electricity to fuel the rise of data centers and the evolution of generative AI.

NRG’s partners in the joint venture are GE Vernova, a provider of renewable energy equipment and services, and TIC – The Industrial Co., a subsidiary of construction and engineering company Kiewit.

“The growing demand for electricity in part due to GenAI and the buildup of data centers means we need to form new, innovative partnerships to quickly increase America’s dispatchable generation,” Robert Gaudette, head of NRG Business and Wholesale Operations, said in a news release. “Working together, these three industry leaders are committed to executing with speed and excellence to meet our customers’ generation needs.”

Initially, the joint venture will work on four projects supplying 5 gigawatts of power from combined-cycle power plants, which uses a combination of natural gas and steam turbines that produce additional electricity from natural gas waste. Electricity from these projects will be produced for power grids operated by the Electric Reliability Council of Texas (ERCOT) and PJM Interconnection. The projects are scheduled to come online from 2029 through 2032.

The joint venture says the model it’s developing for these four projects is “replicable and scalable,” with the potential for expansion across the U.S.

The company is also developing a new 721-megawatt natural gas combined-cycle unit at its Cedar Bayou plant in Baytown, Texas. Read more here.

2 Houston startups join Greentown Labs' BIPOC-led accelerator program

seeing green

Greentown Labs and Browning the Green Space announced the newest cohort for its Advancing Climatetech and Clean Energy Leaders Program, or ACCEL, which works to advance BIPOC-led startups in the climatetech space.

Two Houston companies and one from Austin are among the eight startups to be named to the 2025 group.

“The startups selected for the third ACCEL cohort represent a phenomenal range of energy and climatetech innovations, which underscores our belief that everyone and many solutions must play a role in our community’s collective decarbonization efforts,” Georgina Campbell Flatter, Greentown’s new CEO, said in a release. “We’re proud to welcome these entrepreneurs to our community and eager to see all they’ll achieve throughout the program and beyond!”

Each of the early-stage startups within the cohort will receive $25,000 in non-dilutive grant funding and participate in the year-long program focused on product and technology development, market development, fundraising and management, and team development, according to Greentown. The curriculum is led by VentureWell, a nonprofit with expertise in venture development in climatetech.

The Houston companies include:

  • Carbonext, founded by Olanrewaju Tanimola. The company is leveraging its proprietary, off-the-shelf 3D-graphene technology to develop integrated solutions with carbon-coated silicon anodes to address challenges in the graphite ecosystem, as well as lithium-battery anodes.
  • PLASENE, founded by Sohel Shaikh, Alper Gulludag and Romolo Raciti. The company offers an innovative platform that converts plastic waste into liquid fuel and low-carbon hydrogen through its proprietary catalysts and modular, scalable, pre-engineered units

The remaining six companies are:

  • Inductive Robotics, founded in Austin by Madhav Ayyagari and David Alspaugh. The startup deploys autonomous robots that deliver EV charging directly to parked vehicles in commercial parking facilities, using a subscription-based model.
  • Andros Innovations, founded in Cambridge, Massachusetts by Laron Burrows. The startup has developed a reactor that produces ammonia more cheaply, cleanly and safely than traditional methods do.
  • FAST Metals, founded in Worcester, Massachusetts by Sumedh Gostu and Anthony Staley. It has developed a hydrometallurgical-recovery process capable of extracting iron, aluminum, scandium, titanium, and other rare-earth elements from industrial tailings.
  • Respire Energy, founded in Boston by Dave Hsu, Xiaowei Teng, and Candy Wong. The energy storage startup has developed a safe, low-cost, and long-duration metal-air battery designed for microgrids.
  • Tato Labs, founded in Brooklyn by Mecca McDonald and Mia Dunn. It is developing scalable, innovative, bioplastic products and packaging solutions that leverage potato starch, protect and preserve the natural ecosystem, and minimize plastic waste.
  • Thola, founded in Portland, Maine, by Nneile Nkholise and Lerato Takana. The company provides an on-demand marketplace for commercial-building sustainability and safety management, with a mission to decarbonize old buildings.

ACCEL is supported by the Massachusetts Clean Energy Center (MassCEC), Shell, Equinor, the Growth Capital Division of MassDevelopment, Microsoft and the Barr Foundation.

The accelerator has supported 13 early-stage startups since it was founded in 2023, resulting in $325,000 in grant funding. Houston companies have been represented in each cohort. Click here to see the 2024 cohort and here to see the inaugural 2023 cohort.

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