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New Houston bioindustrial accelerator to spark biotech-based sustainability

supporting startups

The BioWell, founded by biotech investor First Bight Ventures, was established to support sustainability-focused bioindustrial startups. Photo via Getty Images

Bioindustrial technologies have a high potential for impacting sustainability — but they tend to need a little bit more help navigating the startup valley of death. That's where the BioWell comes in.

Carlos Estrada, head of Venture Acceleration at BioWell, says the idea for the accelerator was came to First Bight Ventures, a Houston-based biomanufacturing investment firm, as it began building its portfolio of promising companies.

"While we were looking at various companies, we found ourselves finding different needs that these startups have," Estrada says on the Houston Innovators Podcast. "That's how the opportunity for the BioWell came about."

Specifically, bioindustrial companies, which are tapping into life science innovation to create more sustainable products or services, need early funding, lab space, and strategic corporate partners to help research and develop their startups.

"The very direct challenge that we are seeing is that these companies very often have to spend their funds to build out their own lab spaces," Estrada says, "so by the time they're trying to focus back on the product itself, they are starting to run out of funding."

Carlos Estrada, head of Venture Acceleration at BioWell, joins the Houston Innovators Podcast to share why Houston is already a great hub for bioindustrial innovation. Photo courtesy of BioWell

BioWell is currently selecting its inaugural cohort and is also actively searching for its physical location to build out the program and facilities. Last year, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program from the U.S. Economic Development Administration.

In addition to solving for specific challenges bioindustrial companies face, Estrada says the program will provide support for general startup and entrepreneurial guidance, like business plan development, navigating investors and grant funding, and more.

Just as First Bight Ventures was founded strategically in Houston to make the most of the local resources, the BioWell will operate out of the Bayou City — a market Estrada says has everything the industry needs.

"We have the right talent — our universities produce great researchers. We have the energy companies that are utilizing (a workforce) with transferable skills," he says on the show. "We also have the infrastructure, the square footage, and various real estate companies creating shells for lab space. We have the know how, the universities, and all at a lower cost, which plays a big role in the equation."

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This article originally ran on InnovationMap.

Calling all biotechnology startups focusing on sustainable feedstocks, commercially viable yields, and purpose fit microbes. Photo via Getty Images

Houston organization rolls out new accelerator to support companies tackling 'pressing global challenges'

CALLING FOR APPLICANTS

A Houston organization — freshly funded by a $700,000 U.S. Economic Development Administration’s “Build to Scale” grant — is seeking its first accelerator cohort of industrial biology startups.

Founded by Houston-based First Bight Ventures, the BioWell has launched a virtual accelerator program that will provide programming, networking, mentorship, and financial resources to its inaugural cohort of 10 bioindustrial startups. The selected companies will also have access to specialized pilot bioproduction infrastructure throughout the nine-month program.

“BioWell equips startups with more than just capital. We provide a foundation for breakthrough innovations by combining access to cutting-edge bioproduction facilities with expertise that nurtures scalability. This comprehensive support is crucial for transforming pioneering ideas into market-ready solutions that can address pressing global challenges,” Carlos Estrada, head of venture acceleration at BioWell, says in a news release.

Applications for the program are open until May 15, and the cohort will be announced in June. Specifically, BioWell is seeking seed or pre-seed startup applicants that have a technology readiness level of 3 to 5, focusing on areas including low-cost and sustainable feedstocks, commercially viable yields, and purpose fit microbes.

“During our selection process, we'll prioritize startups that demonstrate a commitment to not only hitting milestones but also to building sustainable revenue streams for long-term survival. This phase necessitates keen awareness of market dynamics, customer demands, and sound financial management,” adds First Bight Ventures and BioWell Founder Veronica Wu.

In December, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

Ex-Apple exec Wu founded First Bight Ventures in Houston in 2022 after relocating from Silicon Valley and seeing the region's potential for biotech.

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This article originally ran on InnovationMap.

First Bight Venture's BioWell has received a $741,925 grant to continue supporting bioindustrial startups. Photo via Getty Images

Houston nonprofit accelerator receives grant funding to advance bioindustrial startups

the biowell

A Houston-based nonprofit accelerator that works with early-stage synthetic biology startups has secured nearly $750,000 to support its mission.

First Bight Ventures' accelerator, BioWell, secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

The funding will support the BioWell's mission to establish a "vibrant bioeconomy" by helping startups scale and commercialize "through access to a unique combination of pilot bioproduction infrastructure," according to a news release from First Bight.

"Startups at BioWell will gain access to a robust ecosystem, expertise, mentorship, and financial resources essential for successfully commercializing their bio-industrial innovations," BioWell Executive Director Paul Palmer says in the release.

The BioWell is still working toward establishing a physical space and has worked out of the East End Maker Hub in the meantime. The organization has partnered with Urban Partnerships Community Development Corporation, or UP CDC, which led the application process on this federal grant.

"BioWell chose to partner with UP CDC for the EDA grant, to continue the successful model that UP CDC has created at the East End Maker Hub for advanced manufacturing. UP CDC looks forward to continuing our partnership with BioWell in the UP CDC's BioCity project that will position Houston at the forefront of bio-manufacturing," UP CDC's CEO Patrick Ezzell says in the release.

First Bight Ventures Founder Veronica Wu established the BioWell to target high-potential startups, which usually have to overcome lack of funding challenges early on.

"Often times, early-stage startups gain momentum and hit important milestones, but ultimately find themselves heading toward the 'Valley of Death,' where progress is made on their enterprise, but no sufficient revenue is generated for the company's stability and longevity," Wu says in the release. "This 'Build to Scale' program's support will help offset these inevitable challenges in our bio-industrial space."

She shares more about her mission for First Bight Ventures on the Houston Innovators Podcast. Listen to the interview from March below.

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This article originally ran on InnovationMap.

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CERAWeek announces winners of annual clean tech pitch competition

top teams

Teams from around the world and right here in Houston took home prizes at the fourth annual Energy Venture Day and Pitch Competition at CERAWeek on March 12.

The fast-paced event, put on by Rice Alliance, Houston Energy Transition Initiative and TEX-E, invited 36 industry startups and five Texas-based student teams focused on driving efficiency and advancements toward the energy transition to present at 3.5-minute pitch before investors and industry partners during CERAWeek's Agora program. The competition is a qualifying event for the Startup World Cup, powered by Pegasus Venture, where teams compete for a $1 million investment prize.

The teams at this year's Energy Venture Day have collectively raised $435 million in funding.

Rice University student teams took home two of the three top prizes in the competition.

HEXASpec won the student track, known at TEX-E, taking home $25,000. The team's pitch focused on enhancing semiconductor chips’ thermal conductivity to boost computing power. Pattern Materials, another Rice-led team, claimed third place and won $10,000 for its proprietary LIG and LIGF technology that produces graphene patterns.

A team from the University of Texas McCombs School of Business, Nanoborne, took home second place and $15,000 for its engineering company focused on research and development in applied nanotechnology.

The companies that pitched in the three industry tracts competed for non-monetary awards. Here's who won:

Track A: Hydrogen, Fuel Cells, Buildings, Water, & Other Energy Solutions

Track B: Advanced Manufacturing, Materials, Fossil Energy, & Carbon Management

Track C: Industrial Efficiency, Decarbonization, Electricity, & the Grid

Arculus Solutions, which retrofits natural gas pipelines for safe hydrogen transportation, was named the overall winner and will move on to the Startup World Cup competition. California-based Membravo was also given a "golden ticket" to participate in the next NOV Supernova Accelerator cohort.

Teams at this year's Energy Venture Day represented five countries and 15 states. Click here to see the full list of companies and investor groups that participated.

CERAWeek, renewables acquisition, and more Houston energy news to know

Trending News

Editor's note: It's time to look back at the top EnergyCapitalHTX stories from the first half of March 2025. CERAWeek 2025 tops the list, along with news of a Houston oil and gas producer expanding into renewables and an NRG Energy joint venture. Read on for the details.

1. 50+ teams announced for CERAWeek's annual clean tech pitch competition

Houston-based Solidec took home the top TEX-E price and $25,000 at last year's Energy Venture Day and Pitch Competition. Photo courtesy of HETI

The Rice Alliance for Technology and Entrepreneurship, the Houston Energy Transition Initiative and the Texas Entrepreneurship Exchange for Energy announced the 30-plus energy ventures and five student teams that would pitch at the 2025 Energy Venture Day and Pitch Competition during CERAWeek.

The ventures are focused on driving efficiency and advancements toward the energy transition and will each present a 3.5-minute pitch before a network of investors and industry partners during CERAWeek's Agora program.

The pitch competition is divided up into the TEX-E university track, in which Texas student-led energy startups compete for $50,000 in cash prizes, and the industry ventures track. Continue reading.

2. Houston oil and gas producer expands into renewables, announces new Baytown facility

Houston American Energy Corp. plans to acquire Abundia Global Impact Group, which will build its first advanced plastic recycling facility in the Cedar Port Industrial Park in Baytown. Photo via Getty Images

Houston American Energy Corp. (NYSE: HUSA), an oil and gas exploration and production company, has entered into a definitive agreement to acquire New York-based Abundia Global Impact Group LLC, which specializes in converting waste into high-value fuels and chemicals.

HUSA is expected to close on the AGIG acquisition early in the second quarter and says the deal aims to provide value through “innovation in the renewable energy sector.” Continue reading.

3. CERAWeek 2025 returns to Houston featuring U.S. energy policy leaders

The CERAWeek by S&P Global 2025 programming will focus on energy policy and the reshaping energy landscape. Photo courtesy of CERAWeek

CERAWeek by S&P Global brought together energy leaders from around the world for its 43rd annual conference, March 10–14, at the Hilton Americas Houston.

U.S. Secretary of Energy Chris Wright and U.S. Secretary of the Interior Doug Burgum headlined the conference with plenary addresses focused on strengthening global energy security.

Wright’s company, Liberty Energy, is also an investor in Houston-based geothermal company Fervo Energy. Burgum also chairs the newly formed White House National Energy Dominance Council and was previously the governor of North Dakota. Continue reading.

4. Supreme Court confronts what to do with growing pile of nuclear waste

Republicans and Democrats, environmental groups and the oil and gas industry all oppose the temporary sites. Photo via uh.edu

The Supreme Court heard arguments in a fight over plans to store nuclear waste at sites in rural Texas and New Mexico. President Joe Biden's administration and a private company with a license for the Texas facility appealed a ruling by the 5th U.S. Circuit Court of Appeals that found that the Nuclear Regulatory Commission exceeded its authority in granting the license. The outcome of the case will affect plans for a similar facility in New Mexico roughly 40 miles away.

On this issue, President Donald Trump's administration is sticking with the views of its predecessor, even with Texas Gov. Greg Abbott, a Republican ally of Trump, on the other side.

The push for temporary storage sites is part of the complicated politics of the nation’s so far futile quest for a permanent underground storage facility. Continue reading.

5. NRG Energy forms joint venture to build power plants for ERCOT and AI-driven demand

A new joint venture will work on four projects supplying 5 gigawatts of power from combined-cycle power plants for the ERCOT and PJM Interconnection grids. Photo via Getty Images.

Houston-based power provider NRG Energy Inc. has formed a joint venture with two other companies to meet escalating demand for electricity to fuel the rise of data centers and the evolution of generative AI.

NRG’s partners in the joint venture are GE Vernova, a provider of renewable energy equipment and services, and TIC – The Industrial Co., a subsidiary of construction and engineering company Kiewit. Continue reading.

Baker Hughes launches major clean energy initiatives with U.S. military and more

clean team

Energy tech company Baker Hughes announced two major clean energy initiatives this month.

The Houston-based company has teamed up with Dallas-based Frontier Infrastructure to develop carbon capture and storage (CCS), power generation and data center operations in the U.S.

Baker Hughes will supply technology for Frontier’s nearly 100,000-acre CCS hub in Wyoming, which will provide open-access CO2 storage for manufacturers and ethanol producers, as well as future Frontier projects. Frontier has already begun drilling activities at the Wyoming site.

“Baker Hughes is committed to delivering innovative solutions that support increasing energy demand, in part driven by the rapid adoption of AI, while ensuring we continue to enable the decarbonization of the industry,” says Lorenzo Simonelli, chairman and CEO of Baker Hughes.

Additionally, Baker Hughes announced this week that it was selected by the U.S. Air Force and the Department of Defense’s Chief Digital and Artificial Intelligence Office (CDAO) to develop utility-scale geothermal power plants that would power global U.S. military bases.

Baker Hughes was granted an "awardable," or eligible, status through the CDAO's Tradewinds Solutions Marketplace, which aims to accelerate "mission-critical technologies," including AI, machine learning and resilient energy technologies. The potential geothermal plants would provide cost-effective electricity, even during a grid outage.

“The ability of geothermal to provide reliable, secure baseload power makes it an ideal addition to America’s energy mix,” Ajit Menon, vice president of geothermal, oilfield services and equipment at Baker Hughes, said in a news release. “Baker Hughes has been a pioneer in this field for more than 40 years and our unique subsurface-to-surface expertise and advanced technology across the geothermal value chain will help the U.S. military unlock this critical domestic energy source, while simultaneously driving economic growth and energy independence.”

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