The BioWell, founded by biotech investor First Bight Ventures, was established to support sustainability-focused bioindustrial startups. Photo via Getty Images

Bioindustrial technologies have a high potential for impacting sustainability — but they tend to need a little bit more help navigating the startup valley of death. That's where the BioWell comes in.

Carlos Estrada, head of Venture Acceleration at BioWell, says the idea for the accelerator was came to First Bight Ventures, a Houston-based biomanufacturing investment firm, as it began building its portfolio of promising companies.

"While we were looking at various companies, we found ourselves finding different needs that these startups have," Estrada says on the Houston Innovators Podcast. "That's how the opportunity for the BioWell came about."

Specifically, bioindustrial companies, which are tapping into life science innovation to create more sustainable products or services, need early funding, lab space, and strategic corporate partners to help research and develop their startups.

"The very direct challenge that we are seeing is that these companies very often have to spend their funds to build out their own lab spaces," Estrada says, "so by the time they're trying to focus back on the product itself, they are starting to run out of funding."

Carlos Estrada, head of Venture Acceleration at BioWell, joins the Houston Innovators Podcast to share why Houston is already a great hub for bioindustrial innovation. Photo courtesy of BioWell

BioWell is currently selecting its inaugural cohort and is also actively searching for its physical location to build out the program and facilities. Last year, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program from the U.S. Economic Development Administration.

In addition to solving for specific challenges bioindustrial companies face, Estrada says the program will provide support for general startup and entrepreneurial guidance, like business plan development, navigating investors and grant funding, and more.

Just as First Bight Ventures was founded strategically in Houston to make the most of the local resources, the BioWell will operate out of the Bayou City — a market Estrada says has everything the industry needs.

"We have the right talent — our universities produce great researchers. We have the energy companies that are utilizing (a workforce) with transferable skills," he says on the show. "We also have the infrastructure, the square footage, and various real estate companies creating shells for lab space. We have the know how, the universities, and all at a lower cost, which plays a big role in the equation."

———

This article originally ran on InnovationMap.

Calling all biotechnology startups focusing on sustainable feedstocks, commercially viable yields, and purpose fit microbes. Photo via Getty Images

Houston organization rolls out new accelerator to support companies tackling 'pressing global challenges'

CALLING FOR APPLICANTS

A Houston organization — freshly funded by a $700,000 U.S. Economic Development Administration’s “Build to Scale” grant — is seeking its first accelerator cohort of industrial biology startups.

Founded by Houston-based First Bight Ventures, the BioWell has launched a virtual accelerator program that will provide programming, networking, mentorship, and financial resources to its inaugural cohort of 10 bioindustrial startups. The selected companies will also have access to specialized pilot bioproduction infrastructure throughout the nine-month program.

“BioWell equips startups with more than just capital. We provide a foundation for breakthrough innovations by combining access to cutting-edge bioproduction facilities with expertise that nurtures scalability. This comprehensive support is crucial for transforming pioneering ideas into market-ready solutions that can address pressing global challenges,” Carlos Estrada, head of venture acceleration at BioWell, says in a news release.

Applications for the program are open until May 15, and the cohort will be announced in June. Specifically, BioWell is seeking seed or pre-seed startup applicants that have a technology readiness level of 3 to 5, focusing on areas including low-cost and sustainable feedstocks, commercially viable yields, and purpose fit microbes.

“During our selection process, we'll prioritize startups that demonstrate a commitment to not only hitting milestones but also to building sustainable revenue streams for long-term survival. This phase necessitates keen awareness of market dynamics, customer demands, and sound financial management,” adds First Bight Ventures and BioWell Founder Veronica Wu.

In December, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

Ex-Apple exec Wu founded First Bight Ventures in Houston in 2022 after relocating from Silicon Valley and seeing the region's potential for biotech.

------

This article originally ran on InnovationMap.

First Bight Venture's BioWell has received a $741,925 grant to continue supporting bioindustrial startups. Photo via Getty Images

Houston nonprofit accelerator receives grant funding to advance bioindustrial startups

the biowell

A Houston-based nonprofit accelerator that works with early-stage synthetic biology startups has secured nearly $750,000 to support its mission.

First Bight Ventures' accelerator, BioWell, secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

The funding will support the BioWell's mission to establish a "vibrant bioeconomy" by helping startups scale and commercialize "through access to a unique combination of pilot bioproduction infrastructure," according to a news release from First Bight.

"Startups at BioWell will gain access to a robust ecosystem, expertise, mentorship, and financial resources essential for successfully commercializing their bio-industrial innovations," BioWell Executive Director Paul Palmer says in the release.

The BioWell is still working toward establishing a physical space and has worked out of the East End Maker Hub in the meantime. The organization has partnered with Urban Partnerships Community Development Corporation, or UP CDC, which led the application process on this federal grant.

"BioWell chose to partner with UP CDC for the EDA grant, to continue the successful model that UP CDC has created at the East End Maker Hub for advanced manufacturing. UP CDC looks forward to continuing our partnership with BioWell in the UP CDC's BioCity project that will position Houston at the forefront of bio-manufacturing," UP CDC's CEO Patrick Ezzell says in the release.

First Bight Ventures Founder Veronica Wu established the BioWell to target high-potential startups, which usually have to overcome lack of funding challenges early on.

"Often times, early-stage startups gain momentum and hit important milestones, but ultimately find themselves heading toward the 'Valley of Death,' where progress is made on their enterprise, but no sufficient revenue is generated for the company's stability and longevity," Wu says in the release. "This 'Build to Scale' program's support will help offset these inevitable challenges in our bio-industrial space."

She shares more about her mission for First Bight Ventures on the Houston Innovators Podcast. Listen to the interview from March below.

———

This article originally ran on InnovationMap.

Greentown Houston has received funding from the EDA. Photo via GreentownLabs.com

Greentown Houston selected for federal program that's accelerating tech entrepreneurship

seeing green

Sixty organizations across the country have received a grant from the United States Department of Commerce — and one recipient is based in Houston.

Greentown Labs, dual located in Houston and Somerville, Massachusetts, has received a grant from the 10th cohort of the Economic Development Administration's “Build to Scale” program for its Houston location. The $53 million of funding was awarded to 60 organizations across 36 states, the District of Columbia, and Puerto Rico. All of the programs support technology entrepreneurs across industries.

“The Biden-Harris Administration is Investing in America to help create entrepreneurial ecosystems across the country and put quality, 21st century job opportunities in people’s backyards,” Secretary of Commerce Gina Raimondo says in the press release. “The ‘Build to Scale’ program will unlock innovation potential in regions all over the nation, improving our economic competitiveness now, and for decades to come.”

According to the EDA, Greentown, located in a growing innovation district, will receive $400,000 with a $400,000 local match confirmed. The project, named Houston Ion District Investor Activation, is described as a way to create economic opportunity through equitable capital access.

"This project capitalizes on the need for jobs and economic development, especially in communities most vulnerable to the impacts of natural disasters," reads the project abstract. "EDA funding will enable the expansion of Greentown’s Investor Program into EDIJ, in partnership with the Ion, to further climate equity and resilience in Houston and empower underrepresented entrepreneurs as the city transitions from fossil fuels to a clean energy economy."

Greentown receives of of the 2023 Capital Challenge Grant Recipients. The other competition, the Venture Challenge, also awarded funding to another Houston organization. The Urban Partnerships Community Development Corporation received $741,925 to support the BioWell Start Accelerator Program, which is committed to scaling of bio-industrial startups.

“EDA is proud to partner with this year’s ‘Build to Scale’ grantees as they fuel regional innovation hubs and technology-based economic development strategies throughout the U.S.,” Assistant Secretary of Commerce for Economic Development Alejandra Y. Castillo says in the release. “Investing in scalable startups and expanding access entrepreneurial capital will yield good-paying jobs, economic resiliency, and equitable growth in communities throughout America.”

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Houston's KBR to provide tech for Kazakhstan's first SAF plant

clean deals

Houston-based engineering and technology firm KBR Inc. has been tapped to provide technology for Kazakhstan's first sustainable aviation fuel (SAF) production plant.

KazMunayGas-Aero LLP (KMG-Aero), a subsidiary of Kazakhstan’s national oil and gas company KazMunayGas, and KazFoodProducts awarded the contract to KBR for the project. The plant will use the alcohol-to-jet (AtJ) process for producing aviation fuel and aims to support President Kassym-Jomart Kemeluly Tokayev’s goal of boosting Kazakhstan's profile as a global aviation player, according to a news release from KBR.

"We are honored to support KMG-Aero and KFP in advancing the national commitment to reduce greenhouse gas emissions, recognizing the pivotal role of aviation decarbonization in achieving these strategic objectives,” Jay Ibrahim, president of KBR Sustainable Technology Solutions, said in the release.

KBR will provide its PureSAF technology and engineering design for the project. Invented and developed by Swedish Biofuels AB, the PureSAF tech will be used to convert alcohol-based feedstocks into SAF. The PureSAF Technology can process multiple feedstocks—like bioethanol, syngas, carbon dioxide and hydrogen—and convert them to SAF, diesel and gasoline, according to KBR.

"KBR’s PureSAF is a feed-flexible, bankable technology that is designed to deliver high SAF yields and supports the project across the full lifecycle,” Ibrahim added in the release. “We look forward to closely collaborating and supporting the successful execution of this landmark SAF project.”

Earlier this summer, KBR was also chosen to provide technology for what’s expected to be Asia's first commercial-scale ethanol-to-jet (SAF) plant. The plant has a planned production capacity of up to 100,000 tons of SAF per year.

In addition to the SAF projects, KBR also announced this month that it has been selected by ORNX Green Hydrogen to provide proprietary ammonia technologies for a low-cost green ammonia project in Morocco.

The commitments come as KBR shifts its focus solely toward sustainability technology and services. The company is in the process of spinning off its Mission Technology Solutions business, which KBR recently announced will be named Trinzic. The remaining company, "New KBR," will serve the ammonia and syngas, chemical and petrochemicals, clean refining and circular economy markets.

Army to build nuclear microreactors at 5 U.S. bases, including Texas

Nuclear News

The U.S. Army announced Wednesday that it plans to add nuclear microreactors at five military bases from New York to Texas as a reliable source of energy independent of the commercial electric grid.

The announcement comes as the Trump administration pushes hard to develop the next generation of nuclear power, including billions in loans for large nuclear reactors to meet skyrocketing power demand from data centers and a pilot program to boost advanced reactor designs and projects for military and civilian use. No nuclear microreactors are supplying power to the commercial electric grid in the United States today.

Five companies selected by the Army will be awarded up to $2.2 billion in total over five years to own, construct and operate the microreactors, if they hit set milestones along the way for their performance. The Army expects that more than 20 nuclear microreactors will be built and operated.

Army and industry officials say microreactors offer a resilient power source for critical infrastructure at military installations in case the grid fails. Reactors can run for years without refueling.

Army Secretary Dan Driscoll said the awards will accelerate the military’s ability “to deliver safe, reliable baseload power directly to our installations. We are building the energy resilience necessary to project combat power globally, without relying on potentially vulnerable external grids,” he said.

The grants are part of the Army's “Janus Program” launched last year to deliver next-generation nuclear energy. Officials hope to push nuclear development forward so that advanced reactor designs move beyond experiments and prototypes to provide power for years to come. This will be the “spear tip,” said Jeff Waksman, principal deputy assistant secretary of the Army for installations, energy and environment.

“That is the transition that we are trying to effect here,” he said on a call with reporters Wednesday. “These are not meant to be Army-specific designs.”

Critics of building more nuclear reactors say they’re too expensive and riskier than other energy sources. The Army program is using the military's “deep pockets to provide a hidden subsidy” to nuclear companies that can't find private-sector customers for their hypothetical and uneconomical reactors, said Alan J. Kuperman, associate professor at the Lyndon B. Johnson School of Public Affairs at the University of Texas at Austin and coordinator of the Nuclear Proliferation Prevention Project.

The reactors will be licensed by the Army, rather than the U.S. Nuclear Regulatory Commission, which licenses commercial nuclear reactors. Kuperman said it's “a dangerous scam on many levels.”

Waksman said these reactors will shut down safely in case of a failure, they're small and the Army wouldn't add them to installations without being certain they are safe. He said the Army is working on a deal with the Energy Department to remove radioactive waste, and there won't be any long-term storage on these installations.

The Army is working to align its regulatory processes as much as possible, Waksman said, so that companies won’t need major changes to their designs to be later licensed by the NRC. Along with federal funding, the Army expects billions of dollars in private capital investment.

Army leads the military’s adoption of nuclear energy

President Donald Trump signed executive orders in May 2025 to speed up the development of nuclear power. The Army was tasked with ensuring that an advanced reactor would start operating at a domestic military installation no later than Sept. 30, 2028. The Janus program is named for the ancient Roman god of transitions.

Officials know that delivering nuclear power to a military base will be a challenge, so they picked five companies in case one or more fail, Waksman said. The selected companies are: Antares Nuclear at Fort Bragg in North Carolina; BWXT at Fort Campbell in Kentucky; General Atomics Electromagnetic Systems at Fort Hood in Texas; Radiant Industries at Fort Benning in Georgia; and Westinghouse Government Services at Fort Drum in New York.

Senate Minority Leader Chuck Schumer asked the Army to select Fort Drum. The critical missions Fort Drum supports require secure power generation, the New York Democrat said.

The military installations will remain connected to the grid. The reactors would not completely power them. Each reactor will provide between 1 megawatt to 20 megawatts of power, depending on the company's design. Major bases use as much power as a small city. Antares and Radiant are planning to deliver their reactors in three-packs, Waksman said.

The Army now uses diesel as a primary backup for critical infrastructure. But in a conflict, Waksman said, the Army may not be able to move fossil fuels easily wherever it needs them.

“That makes nuclear energy just a natural game changer,” he said. “It makes sense for the Army to take the lead here.”

A reactor at Fort Belvoir in Virginia, completed in 1957, was the first nuclear power reactor to provide electricity to a commercial power grid in the United States for an extended period, according to the U.S. Army Corps of Engineers.

Companies say this will accelerate US nuclear development

California-based Antares reached a crucial milestone under the U.S. pilot program that could allow it to produce electricity at Idaho National Lab next year. The company said the Army's announcement extends its momentum. Westinghouse Government Services said it’s proud to support the Army’s efforts to strengthen energy security and innovate.

Tori Shivanandan, president and chief operating officer of California-based Radiant, said the Army’s $750 million award “shows confidence in Radiant’s product and ability to manufacture, deploy and safely operate nuclear microreactors for the American military.” The Janus program “will build a stronger and more resilient America,” she said.

General Atomics Electromagnetic Systems said its reactor is designed to operate in remote, off-grid and extreme environments for 40 years. It said it will draw on more than 70 years of nuclear expertise to provide safe, dependable and independent power for the military.

Rex Geveden, BWXT's president and chief executive officer, said, “As we commence work on the Janus program, we are delivering the nation’s most credible and reliable path to deployable nuclear power.”

Energy giant Shell lists Houston HQ for sale for $325 million

asset offload

Energy giant Shell has put its U.S. headquarters in Houston’s Energy Corridor on the market and is exploring the sale of its U.S. chemical business.

Green Street News reported Shell just listed its longtime Energy Corridor campus at 150 N. Dairy Ashford Road. The asking price is $325 million, The Real Deal reported. Shell plans to lease back half of the nearly 1.5 million-square-foot Woodcreek campus for 15 years.

A sale-leaseback deal could transform the 43.6-acre campus into a multitenant hub, CoStar News reported.

“Houston is a critical hub for Shell globally and the headquarters of our U.S. businesses,” a Shell spokesperson told the Houston Business Journal. “We remain committed to Houston and are evaluating opportunities to optimize our Woodcreek campus as part of our ongoing review of workplace needs while maintaining a strong presence in the city.”

Shell occupied its first building at the West Houston campus in 1980. The company employs more than 6,000 people in Texas.

Shell is one of the highest-profile businesses occupying space in the Energy Corridor. It’s home to 67,000 workers, more than 27 million square feet of office and mixed-use space, and 3.8 million square feet of retail and restaurant space.

Shell considers $8B sale of chemical business

As the company seeks to unload its Woodcreek campus, The Financial Times reported Shell is looking into selling its U.S. chemical business. The price tag: $8 billion.

Potential buyers include Spring-based ExxonMobil and Houston-based LyondellBasell.

Shell operates four chemical plants in Texas, Louisiana and Pennsylvania, producing an array of chemicals for use in plastics, detergents and pharmaceuticals.

Shell CEO Wael Sawan said last year that the company had spent $45 billion in capital “that is underperforming for us,” split between its chemical business and renewable energy arm.

Shell also agreed to sell its solar and wind power business in India this summer. Read more here.