Houston organization rolls out new accelerator to support companies tackling 'pressing global challenges'

CALLING FOR APPLICANTS

Calling all biotechnology startups focusing on sustainable feedstocks, commercially viable yields, and purpose fit microbes. Photo via Getty Images

A Houston organization — freshly funded by a $700,000 U.S. Economic Development Administration’s “Build to Scale” grant — is seeking its first accelerator cohort of industrial biology startups.

Founded by Houston-based First Bight Ventures, the BioWell has launched a virtual accelerator program that will provide programming, networking, mentorship, and financial resources to its inaugural cohort of 10 bioindustrial startups. The selected companies will also have access to specialized pilot bioproduction infrastructure throughout the nine-month program.

“BioWell equips startups with more than just capital. We provide a foundation for breakthrough innovations by combining access to cutting-edge bioproduction facilities with expertise that nurtures scalability. This comprehensive support is crucial for transforming pioneering ideas into market-ready solutions that can address pressing global challenges,” Carlos Estrada, head of venture acceleration at BioWell, says in a news release.

Applications for the program are open until May 15, and the cohort will be announced in June. Specifically, BioWell is seeking seed or pre-seed startup applicants that have a technology readiness level of 3 to 5, focusing on areas including low-cost and sustainable feedstocks, commercially viable yields, and purpose fit microbes.

“During our selection process, we'll prioritize startups that demonstrate a commitment to not only hitting milestones but also to building sustainable revenue streams for long-term survival. This phase necessitates keen awareness of market dynamics, customer demands, and sound financial management,” adds First Bight Ventures and BioWell Founder Veronica Wu.

In December, BioWell secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

Ex-Apple exec Wu founded First Bight Ventures in Houston in 2022 after relocating from Silicon Valley and seeing the region's potential for biotech.

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This article originally ran on InnovationMap.

First Bight Venture's BioWell has received a $741,925 grant to continue supporting bioindustrial startups. Photo via Getty Images

Houston nonprofit accelerator receives grant funding to advance bioindustrial startups

the biowell

A Houston-based nonprofit accelerator that works with early-stage synthetic biology startups has secured nearly $750,000 to support its mission.

First Bight Ventures' accelerator, BioWell, secured $741,925 of the $53 million doled out as a part of the "Build to Scale" Grant program that the U.S. Economic Development Administration, a division of the U.S. Department of Commerce, has established. First Bight was one of 60 organizations to receive funding.

The funding will support the BioWell's mission to establish a "vibrant bioeconomy" by helping startups scale and commercialize "through access to a unique combination of pilot bioproduction infrastructure," according to a news release from First Bight.

"Startups at BioWell will gain access to a robust ecosystem, expertise, mentorship, and financial resources essential for successfully commercializing their bio-industrial innovations," BioWell Executive Director Paul Palmer says in the release.

The BioWell is still working toward establishing a physical space and has worked out of the East End Maker Hub in the meantime. The organization has partnered with Urban Partnerships Community Development Corporation, or UP CDC, which led the application process on this federal grant.

"BioWell chose to partner with UP CDC for the EDA grant, to continue the successful model that UP CDC has created at the East End Maker Hub for advanced manufacturing. UP CDC looks forward to continuing our partnership with BioWell in the UP CDC's BioCity project that will position Houston at the forefront of bio-manufacturing," UP CDC's CEO Patrick Ezzell says in the release.

First Bight Ventures Founder Veronica Wu established the BioWell to target high-potential startups, which usually have to overcome lack of funding challenges early on.

"Often times, early-stage startups gain momentum and hit important milestones, but ultimately find themselves heading toward the 'Valley of Death,' where progress is made on their enterprise, but no sufficient revenue is generated for the company's stability and longevity," Wu says in the release. "This 'Build to Scale' program's support will help offset these inevitable challenges in our bio-industrial space."

She shares more about her mission for First Bight Ventures on the Houston Innovators Podcast. Listen to the interview from March below.

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This article originally ran on InnovationMap.

Houston VC invests in early stage California biodegradable plastics startup

seed funding

Houston-based venture capital firm First Bight Ventures led a $5 million seed round for Encinitas, California-based startup Algenesis, a developer of biodegradable plastics.

Algenesis bills its patented Soleic technology as the world’s first renewable, high-performance, fully biodegradable, and backyard-compostable polyurethane made from plants and algae. Each year, 25 million tons of hard-to-recycle polyurethane are produced for the footwear, medical, and textile industries. Polyurethane, typically made from petroleum, usually ends up as landfill waste or environmental microplastics.

Algenesis says Soleic can biodegrade in compost within a matter of months and does not contain harmful PFAS chemicals found in other plastics.

Algenesis says the new funding will enable it to expand beyond soft-foam applications, such as midsoles and insoles for footwear, and into injection-molded products such as smartphone cases along with waterproof textiles.

Aside from First Bight Ventures, investors in the seed round are Singapore-based Circulate Capital, India-based MIH Capital, Chesapeake, Virginia-based Diamond Sports Group, and France-based Rhinoshield.

The investment comes on the heels of a $5 million grant Algenesis received from the U.S. Department of Energy to scale up production of biochemicals.

“To save our planet and ourselves, we must move away from petroleum-based plastics and toward bio-based alternatives. Algenesis is clearly at the forefront of making this possible,” says Veronica Wu, founder of First Bight Ventures.

First Bight, which launched in 2022, invests in early-stage startups working on synthetic biology.

“First Bight is investing to bring the best and the brightest — and most promising — synthetic biology startups from around the country to Houston,” Wu said last year.

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Geothermal energy startup's $600M deal fuels surge in Houston VC funding

by the numbers

The venture capital haul for Houston-area startups jumped 23 percent from 2023 to 2024, according to the latest PitchBook-NVCA Venture Monitor.

The fundraising total for startups in the region climbed from $1.49 billion in 2023 to $1.83 billion in 2024, PitchBook-NVCA Venture Monitor data shows.

Roughly half of the 2024 sum, $914.3 million, came in the fourth quarter. By comparison, Houston-area startups collected $291.3 million in VC during the fourth quarter of 2023.

Among the Houston-area startups contributing to the impressive VC total in the fourth quarter of 2024 was geothermal energy startup Fervo Energy. PitchBook attributes $634 million in fourth-quarter VC to Fervo, with fulfillment services company Cart.com at $50 million, and chemical manufacturing platform Mstack and superconducting wire manufacturer MetOx International at $40 million each.

Across the country, VC deals total $209 billion in 2024, compared with $162.2 billion in 2023. Nearly half (46 percent) of all VC funding in North America last year went to AI startups, PitchBook says. PitchBook’s lead VC analyst for the U.S., Kyle Stanford, says that AI “continues to be the story of the market.”

PitchBook forecasts a “moderately positive” 2025 for venture capital in the U.S.

“That does not mean that challenges are gone. Flat and down rounds will likely continue at higher paces than the market is accustomed to. More companies will likely shut down or fall out of the venture funding cycle,” says PitchBook. “However, both of those expectations are holdovers from 2021.”

This story originally appeared on our sister site, InnovationMap.com.

Halliburton's clean energy cohort tops trending news for January 2025

Trending News Tidbits

Editor's note: We're taking a look back at the top energy transition headlines from the second half of January 2025. Here are the five most-read EnergyCaptialHTX stories, from Halliburton's new clean energy cohort to Texas' top ranking among U.S. manufacturing hubs.

1. Halliburton names 5 clean energy startups to latest incubator cohort

Texas-based 360 Energy is part of Halliburton's new clean energy cohort. Photo courtesy of 360 Energy

Halliburton Labs has named five companies to its latest cohort, including one from Texas. All of the companies are working to help accelerate the future of the energy industry in different ways. The incubator aims to advance the companies’ commercialization with support from Halliburton's network, facilities and financing opportunities. Continue reading.

2. Houston Auto Show returns this month as part of new innovative coalition

The Houston Auto Show and Houston Boat Show (Houston AutoBoative) run from Jan. 2–Feb. 2. Photo via Houston Auto Show/Facebook

The Houston Auto Show and Houston Boat Show (Houston AutoBoative) returned to NRG Center this month, and for the first time, the popular events are part of the Automotive Experience Alliance (AEA). Launched in October, the AEA is a coalition of about 30 auto shows that aim to drive innovation and standardization throughout the auto show industry. Continue reading.

3. Being prepared: Has the Texas grid been adequately winterized?

How has the Texas grid improved since Winter Storm Uri in 2021? Getty Images

As Houston braced for historic winter weather, guest columnist Sam Luna, director at BKV Energy, asked the question on many Texans' minds each winter. In this article, Luna explores how the Texas grid has improved since Winter Storm Uri in 2021. Continue reading.

4. Geothermal exec on Houston expansion, commercialization and more

Axel-Pierre Bois, XGS Energy's Chief Technology Officer. Photo courtesy XGS Energy

Challenges in energy transition often center around two questions: Where will organizations find the resources? And how will projects be financed? XGS Energy's next-gen closed-loop geothermal well architecture addresses both issues head-on. The California-based company saw massive growth in the Houston market last year and recently completed a 100-meter field demonstration in central Texas, marking a major milestone for its technology's commercialization and potential for scale. In an interview with EnergyCapital, Axel-Pierre Bois, XGS's Chief Technology Officer, shares what drew him to the geothermal space, why XGS is expanding in Houston and what the company's plans are for the year ahead. Continue reading.

5. Texas ranks as No. 2 manufacturing hub in U.S., behind only California

A new study puts Texas at No. 2 among the states when it comes to manufacturing. Photo via Getty Images

Texas ranks among the country’s biggest hubs for manufacturing, according to a new study. The study, conducted by Chinese manufacturing components supplier YIJIN Hardware, puts Texas at No. 2 among the states when it comes to manufacturing-hub status. California holds the top spot. Continue reading.

Houston researchers harness dialysis for new wastewater treatment process

waste not

By employing medical field technology dialysis, researchers at Rice University and the Guangdong University of Technology in China uncovered a new way to treat high-salinity organic wastewater.

In the medical field, dialysis uses a machine called a dialyzer to filter waste and excess fluid from the blood. In a study published in Nature Water, Rice’s team found that mimicking dialysis can separate salts from organic substances with minimal dilution of the wastewater, addressing some of the limitations of previous methods.

The researchers say this has the potential to lower costs, recover valuable resources across a range of industrial sectors and reduce environmental impacts.

“Traditional methods often demand a lot of energy and require repeated dilutions,” Yuanmiaoliang “Selina” Chen, a co-first author and postdoctoral associate in Elimelech’s lab at Rice, said in a news release. “Dialysis eliminates many of these pain points, reducing water consumption and operational overheads.”

Various industries generate high-salinity organic wastewater, including petrochemical, pharmaceutical and textile manufacturing. The wastewater’s high salt and organic content can present challenges for existing treatment processes. Biological and advanced oxidation treatments become less effective with higher salinity levels. Thermal methods are considered “energy intensive” and susceptible to corrosion.

Ultimately, the researchers found that dialysis effectively removed salt from water without requiring large amounts of fresh water. This process allows salts to move into the dialysate stream while keeping most organic compounds in the original solution. Because dialysis relies on diffusion instead of pressure, salts and organics cross the membrane at different speeds, making the separation method more efficient.

“Dialysis was astonishingly effective in separating the salts from the organics in our trials,” Menachem Elimelech, a corresponding author on the study and professor of civil and environmental engineering and chemical and biomolecular engineering at Rice, said in a news release. “It’s an exciting discovery with the potential to redefine how we handle some of our most intractable wastewater challenges.”

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